In normal epithelium, the staining pattern was cytoplasmic and polarized at the cellular free edge. Confocal laser scanning microscopical investigation was also performed. The specificity of the antibody was verified by Western Blot analysis. Twenty-five samples composed of five normal nasal epithelia and 20 canine nasal carcinomas, were immunohistochemically stained for PPAR-gamma. In this study, we investigated the expression of PPAR-gamma in normal and neoplastic canine nasal epithelium. In addition to adipogenic and anti-inflammatory effects, PPAR-gamma activation has been shown to be anti-proliferative by its differentiation-promoting effect, suggesting that activation of PPAR-gamma may be useful in slowing or arresting the proliferation of de-differentiated tumour cells. PPAR-gamma is expressed in multiple normal and neoplastic tissues, such as the breast, colon, lung, ovary and placenta. ![]() Peroxisome proliferator- activated receptor gamma ( PPAR-gamma) is a ligand- activated transcriptional factor belonging to the steroid receptor superfamily. Paciello, O Borzacchiello, G Varricchio, E Papparella, S Expression of peroxisome proliferator- activated receptor gamma ( PPAR-gamma) in canine nasal carcinomas.
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